GZR18 + metformin

GZR18 + metformin is a combination of two agents under investigation and use for the treatment of type 2 diabetes mellitus and potentially obesity. GZR18 is a novel, long-acting analog of glucagon-like peptide 1 (GLP-1), an incretin hormone that stimulates insulin secretion and inhibits glucagon release in response to elevated blood glucose. It has demonstrated efficacy in lowering blood glucose, reducing glycated hemoglobin, and decreasing food intake in preclinical models. Metformin is a well-established oral antihyperglycemic agent from the biguanide class that decreases hepatic glucose production, reduces intestinal absorption of glucose, and increases insulin sensitivity by enhancing peripheral uptake and utilization of glucose. The combination aims to leverage complementary mechanisms for improved glycemic control[1][4][6][8].

Brand names

GlucophageGlucophage XR

Other names

GZR18 + metformin