H-151

H-151 is a potent, irreversible, and selective small molecule inhibitor of the stimulator of interferon genes (STING) protein. It acts by covalently binding to the transmembrane cysteine residue at position 91 (Cys91) of STING, thereby blocking its palmitoylation and clustering—two essential steps for STING signaling. This inhibition prevents downstream activation processes such as type I interferon response and pro-inflammatory cytokine production. H-151 has demonstrated significant anti-inflammatory and antiviral effects in preclinical models by reducing cytokine signaling. It is being investigated primarily for autoinflammatory diseases where aberrant STING activation plays a role[3][5][6].

Other names

N-(4-Ethylphenyl)-N’-1H-indol-3-yl-urea