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h-CPL Associates-maxillary sinusitis
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
The entry **h-CPL Associates-maxillary sinusitis** refers to a clinical research context or specific Phase 4 trial (NCT00120237) managed by **CPL Associates** that evaluated the comparative efficacy and microflora impact of two established antibiotics, **telithromycin** and **azithromycin**, in adult patients with **acute maxillary sinusitis (AMS)**. Telithromycin is a ketolide antibiotic, while azithromycin is a macrolide; both agents exert their antimicrobial effects by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting RNA-dependent protein synthesis. The study specifically investigated the speed of microbial eradication and the influence of these oral antibiotics on the endogenous oral microflora and the development of bacterial resistance patterns. CPL Associates acted as the lead sponsor for this post-marketing evaluation.
- Other names
- Telithromycin vs. Azithromycin in Acute Maxillary Sinusitis Study
02
Targets
23S rRNA (23S ribosomal RNA)
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