Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
H-His-D-Arg-Ala-Trp-D-Phe-Lys-NH2
- Development stage
- Unknown
- Lead developer
- University of Arizona
- Modality
- Peptides
- Administration
- Topical, Subcutaneous
01
Overview
H-His-D-Arg-Ala-Trp-D-Phe-Lys-NH2 is a synthetic hexapeptide that acts as a competitive antagonist of alpha-melanocyte-stimulating hormone (alpha-MSH). It was developed as a pharmacological tool to study the melanocortin system, specifically targeting the melanocortin 1 receptor (MC1R). The peptide is structurally related to growth hormone-releasing peptides (GHRPs) but contains a D-Arginine substitution at the second position, which eliminates growth hormone-releasing activity and confers potent MSH-antagonistic properties. Research has demonstrated its ability to inhibit MSH-induced skin darkening in various vertebrate species, such as the leopard frog (*Rana pipiens*) and the tree lizard (*Urosaurus ornatus*). However, its biological activity is highly species-specific, as it has been found to be inactive in certain mammalian systems, including murine melanoma cells.
- Other names
- alpha-MSH antagonist hexapeptideMSH antagonist hexapeptideHis-D-Arg-Ala-Trp-D-Phe-Lys-NH2His-D-Arg-Ala-Trp-D-Phe-Lys-NH-2His-D-Arg-Ala-Trp-D-Phe-Lys-NH 2
02
Targets
MC1R (Melanocortin Type 1 Receptor)
Beyond the preview
Go deeper on H-His-D-Arg-Ala-Trp-D-Phe-Lys-NH2.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on H-His-D-Arg-Ala-Trp-D-Phe-Lys-NH2.