h-Johns Hopkins University-opioid dependence

The identifier **h-Johns Hopkins University-opioid dependence** refers to a research program and clinical trial series led by Johns Hopkins University, most notably the **MOTHER (Maternal Opioid Treatment: Human Experimental Research)** study. This Phase 3, randomized, double-blind trial compared the efficacy and safety of **buprenorphine** (a partial mu-opioid agonist) and **methadone** (a full mu-opioid agonist) for the treatment of opioid dependence in pregnant women. The primary objective was to evaluate neonatal outcomes, specifically the incidence and severity of Neonatal Abstinence Syndrome (NAS). The study demonstrated that while both medications were effective for maternal stabilization, buprenorphine-exposed neonates required significantly less morphine for NAS treatment and had shorter hospital stays compared to those exposed to methadone.

Other names

Buprenorphine vs Methadone in Pregnant Women