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H-Ras antisense oligodeoxynucleotide ISIS 2503
- Development stage
- Phase 2
- Lead developer
- Ionis Pharmaceuticals
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
ISIS 2503 is a synthetic, 20-base phosphorothioate antisense oligodeoxynucleotide designed to hybridize to the translation initiation region of human H-Ras mRNA. By binding specifically to this sequence, it selectively inhibits the expression of H-Ras, an oncogene implicated in the development and maintenance of various cancers. This targeted inhibition may suppress tumor cell growth in Ras-dependent tumors while sparing other members of the Ras protein family. Developed as an anti-cancer agent, ISIS 2503 has been evaluated primarily for pancreatic cancer and also investigated in metastatic breast cancer and non-small cell lung cancer. The drug was developed by Isis Pharmaceuticals (now Ionis Pharmaceuticals) and reached Phase II clinical trials[1][2][3][5][7].
- Other names
- h-ras antisense oligodeoxynucleotide isis 2503
02
Targets
HRAS (H-Ras protein)
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