H1152

H1152 is a highly selective, potent, and ATP-competitive small molecule inhibitor of Rho-kinase (ROCK), primarily inhibiting ROCKII with markedly less affinity for other kinases. It is membrane permeable and exhibits much greater specificity and potency for ROCK enzymes than earlier ROCK inhibitors such as Y27632. H1152 displays biological activities such as inhibiting stress fiber formation, promoting neurite extension, preventing fragmentation of apoptotic cells, displaying pro-erectile effects in animal models, and reducing neuropathic pain. It is widely used as a research tool for studying ROCK signaling, neuronal differentiation, and cell motility and contraction[1][2][3][4][6].

Other names

H-1152 dihydrochlorideH1152 dihydrochlorideH 1152 dihydrochloride(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine dihydrochlorideH-1152P . 2HClH1152P . 2HClH 1152P . 2HCl