Drug intelligence / Profile preview

h1B8

Development stage
Preclinical
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
01

Overview

h1B8 is an experimental **humanized monoclonal antibody** directed against **receptor tyrosine kinase-like orphan receptor 1**. It was reported in preclinical research as a high-specificity, high-affinity anti-ROR1 antibody with antitumor activity in lung cancer, liver cancer, and breast cancer mouse models. The published work also noted comparatively strong target-mediated internalization versus another anti-ROR1 antibody, suggesting potential suitability as a future **antibody-drug conjugate** backbone, although h1B8 itself was described as an unconjugated antibody in the available source material. No specific commercial developer or manufacturer was clearly identified from the provided evidence.

02

Targets

ROR1 (Receptor tyrosine kinase-like orphan receptor 1)

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