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H5-VLP + GLA-AF (Access to Advanced Health Institute)
- Development stage
- Phase 1
- Lead developer
- Access to Advanced Health Institute
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
H5-VLP + GLA-AF is an investigational pandemic influenza vaccine candidate developed by the Access to Advanced Health Institute (AAHI). The vaccine formulation consists of recombinant influenza virus H5 protein (hemagglutinin derived from the A/Indonesia/5/2005 strain) produced in a plant-based expression system that assembles into virus-like particles (VLPs). This antigen is combined with GLA-AF (Glucopyranosyl Lipid Adjuvant-Aqueous Formulation), a synthetic Toll-like receptor 4 (TLR4) agonist designed to enhance the magnitude and durability of the immune response. The vaccine is intended to prevent infection by the H5N1 subtype of the influenza A virus by inducing neutralizing antibodies against the viral hemagglutinin.
- Other names
- H5-VLP + GLA-AF pandemic influenza vaccineH5-VLP plus GLA-AFH-5-VLP plus GLA-AFH 5-VLP plus GLA-AF
02
Targets
HA (Hemagglutinin)TLR4 (Toll-like receptor 4)
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