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H6-MSA

Development stage: Preclinical
Lead developer: McMaster University
Modality: Recombinant Proteins and Enzymes
Administration: Intravenous

Overview

H6-MSA is a recombinant, hexahistidine-tagged version of murine serum albumin (MSA) expressed in the yeast *Pichia pastoris*. Developed by researchers at McMaster University and Canadian Blood Services, it serves as a pharmacokinetic control protein in studies investigating extended half-life (EHL) strategies for Hereditary Angioedema (HAE) treatments. The protein leverages the neonatal Fc receptor (FcRn) recycling pathway to maintain a prolonged circulatory residency time, exhibiting a terminal half-life of approximately 21.4 hours in murine models. Its primary utility is as a benchmark for evaluating the efficacy of albumin-fusion platforms, such as those involving truncated C1 esterase inhibitor (C1INH) variants.

Other names: hexahistidine-tagged murine serum albuminrecombinant murine serum albuminH6-tagged MSAH-6-tagged MSAH 6-tagged MSA

Targets

FCGRT (Neonatal crystallizable fragment receptor)

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