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hAB21
- Development stage
- Preclinical
- Modality
- IgG Antibodies → Naked Antibodies → Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Intraperitoneal, Subcutaneous, Intramuscular, Intraarterial
01
Overview
Humanized AB21 (hAB21) is a pan-allelic anti-SIRPα antibody that blocks the interaction between Signal regulatory protein α (SIRPα) and its ligand CD47. This blockade enhances macrophage-mediated antibody-dependent phagocytosis of tumor cells and promotes anti-tumor activity. It has demonstrated improved responses in combination with rituximab in mouse xenograft models and with PD-1/PD-L1 blockade in syngeneic models, leading to the activation of monocytes, dendritic cells, and T cell effector functions. hAB21 is being developed as a potential therapeutic intervention for human malignancies.
- Brand names
- AB21AB-21AB 21
- Other names
- humanized AB21
02
Targets
SIRPA (Signal-regulatory protein alpha)CD47 (Cluster of Differentiation 47)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)
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