HAC-Y6

**HAC-Y6** is a novel synthetic small-molecule compound described as 6-acetyl-9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indole. It acts as a potent microtubule-depolymerizing agent, causing microtubule fragmentation and inhibition of α- and β-tubulin assembly, similar to colchicine. HAC-Y6 induces cell cycle arrest at the G2/M phase and triggers apoptosis through both intrinsic (mitochondrial) and extrinsic (death receptor 4) pathways. Molecular mechanisms implicated include activation of Bax and caspases 3/8/9, inactivation of Bcl-2 and Bcl-xL, upregulation of BubR1, and inhibition of HSP90, with additional inactivation of aurora A and aurora B kinases. Preclinical studies show antitumor activity against human hepatocellular carcinoma and colon carcinoma cell lines[1][4].

Other names

6-acetyl-9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indole