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hadacidin
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Unknown (no Established Pharmaceutical Formulation Or Approved Route)
01
Overview
Hadacidin is a naturally occurring small molecule and the simplest known hydroxamic acid. It was originally isolated from cultures of Penicillium frequentans. Structurally, it is an N-formyl-N-hydroxy derivative of glycine. Hadacidin acts as a competitive inhibitor of adenylosuccinate synthetase (also called adenylate synthase), an enzyme involved in purine biosynthesis. This inhibition disrupts nucleotide metabolism and has been shown to confer antineoplastic (anticancer) activity in preclinical models and early clinical trials. Additionally, hadacidin exhibits antimicrobial properties and has been studied for its effects on tumor growth inhibition[2][4][6][7].
- Brand names
- HAD
- Other names
- asymmetrinhadacidineN-formyl-N-hydroxyglycineN-formyl-N-hydroxyaminoacetic acidglycine N-formyl-N-hydroxy-2-[formyl(hydroxy)amino]acetic acid
02
Targets
ADSS2 (Adenylosuccinate synthetase)
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