Haihe Biopharma ENPP1 compound 27

Haihe Biopharma ENPP1 compound 27: sourced facts only. name: "Herein, we report our effort in the design and synthesis of two different series of ENPP1 inhibitors, and in the identification of a highly potent ENPP1 inhibitor 27 (IC50 = 1.2 nM at pH 7.5), which significantly enhanced the cGAMP-mediated STING activity in THP-1 cells." [PMID:39270452]; target: "Herein, we report our effort in the design and synthesis of two different series of ENPP1 inhibitors, and in the identification of a highly potent ENPP1 inhibitor 27 (IC50 = 1.2 nM at pH 7.5), which significantly enhanced the cGAMP-mediated STING activity in THP-1 cells." [PMID:39270452]; developer: "Discovery & Early Development, Haihe Biopharma Co., Ltd., No 865, Zuchongzhi Road, Zhangjiang Science City, Shanghai, 201203, China." [PMID:39270452]; modality: "Phosphonate compound 27 has good preclinical pharmacokinetic profiles with low plasma clearance rate in mouse, rat, and dog." [PMID:39270452]