haizao xiaoyu decoction

Haizao Xiaoyu Decoction is a classic multi-herb formula in traditional Chinese medicine (TCM), historically used for over 500 years primarily to treat goiter and other thyroid-related diseases. The formula is notable for containing both Glycyrrhiza (licorice root) and Sargassum (seaweed), which are traditionally considered incompatible in TCM but have demonstrated synergistic effects in this context. The main mechanism of action involves inhibition of angiogenesis and cell proliferation in goiter tissue, primarily through suppression of the PI3K-Akt signaling pathway. Modern pharmacological studies confirm its efficacy against goiter, with additional benefits such as antioxidative activity and modulation of thyroid hormone levels[1][3][10]. The formula contains multiple active compounds including glycyrrhizinic acid, liquiritin, nobiletin, osthole, 6-gingerol, honokiol among others[4][6]. It is typically prepared as a water-based herbal decoction.

Brand names

haizao xiaoyu decoction

Other names

HYDHaizao Yuhu Decoction海藻消瘤汤 (Chinese)Haizao Xiaoyu Tang