Drug intelligence / Profile preview

HalfLytely and Bisacodyl

Development stage
Unknown
Lead developer
Braintree
Modality
Small Molecules
Administration
Oral
01

Overview

HalfLytely and Bisacodyl is a combination bowel preparation kit used primarily for cleansing the colon prior to colonoscopy in adults. The kit contains two main components: - Polyethylene glycol 3350 (PEG-3350) with electrolytes (sodium chloride, sodium bicarbonate, potassium chloride), which acts as an osmotic laxative by retaining water in the gastrointestinal tract to induce watery diarrhea. - Bisacodyl delayed-release tablets, a stimulant laxative that is hydrolyzed by intestinal enzymes and colonic bacteria into its active metabolite [bis-(p-hydroxyphenyl) pyridyl-2 methane; BHPM], which stimulates colonic peristalsis by acting directly on the colonic mucosa. The combined action of these agents results in effective bowel cleansing through both increased water retention (osmotic effect) and enhanced intestinal motility (stimulant effect). The product is administered orally as part of a split-dose regimen before procedures requiring clear visualization of the colon[1][2][3][4][6][8].

Brand names
HalfLytely and BisacodylHalfLytely and Bisacodyl Tablet Bowel Prep Kit
02

Targets

AQP3 (Aquaporin-3 channel protein)

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