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Haoqin Huaban Fang
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Haoqin Huaban Fang is a traditional Chinese medicine (TCM) decoction used for the treatment of skin conditions related to phototoxicity and UVB-induced damage, such as polymorphic light eruption. The formula is based on the principle of clearing heat, cooling blood, and detoxifying. It has been studied for its protective effects against UVB-induced oxidative stress and inflammation in skin cells. Mechanistically, it upregulates HOXA11-AS expression by activating hypoxia-inducible factor 1α (HIF-1α), stabilizes EZH2 protein by inhibiting its ubiquitination and proteasomal degradation, reduces oxidative stress, promotes cell proliferation, and inhibits apoptosis in HaCaT cells[4][1].
- Brand names
- No specific brand name found; typically referred to by its Chinese name or formula name
- Other names
- 蒿秦化斑方
02
Targets
HOXA11-AS (HOXA11 antisense RNA)HIF1A (Hypoxia-inducible factor 1-alpha)EZH2 (Histone-lysine N-methyltransferase EZH2)
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