Haplo-Cord Transplant

Haplo-Cord Transplant is a specialized allogeneic hematopoietic stem cell transplantation (HSCT) protocol that combines a haploidentical (half-matched) donor graft with an umbilical cord blood (UCB) unit. Developed and pioneered at the University of Chicago, this approach is designed to overcome the limitations of both individual graft types: the haploidentical graft provides rapid, early myeloid engraftment to reduce the period of post-transplant neutropenia, while the cord blood unit provides long-term, durable hematopoiesis and a potent graft-versus-leukemia (GVL) effect. In the context of the Rapid Study (NCT02743819), this protocol is being evaluated as a strategy to expedite the transplant process for patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS) who lack a matched sibling donor, comparing the time-to-transplant against the standard search for a matched unrelated donor (MUD). The haploidentical portion of the graft may undergo selection or processing using specialized devices, such as those from Miltenyi Biotec, to optimize the cell composition.

Other names

Haplo-CordHaploidentical Plus Unrelated Cord Donor SearchHaploidentical-Cord Blood Transplantation