Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Haploidentical Bone Marrow Transplantation
- Development stage
- Phase 2
- Lead developer
- Johns Hopkins Medicine
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Haploidentical Bone Marrow Transplantation (Haplo-BMT) is an allogeneic hematopoietic stem cell transplant procedure utilizing a donor who is a partial human leukocyte antigen (HLA) match, typically a biological parent, child, or sibling. This specific protocol, evaluated by the Medical College of Wisconsin in the BMT CTN 0603 trial, employs a nonmyeloablative conditioning regimen consisting of fludarabine, cyclophosphamide, and low-dose total body irradiation (TBI). To mitigate the high risk of graft-versus-host disease (GVHD) and graft rejection associated with HLA mismatch, the protocol utilizes high-dose post-transplantation cyclophosphamide (PTCy) on days 3 and 4. PTCy selectively depletes proliferating alloreactive T cells from the donor graft while sparing non-alloreactive T cells and hematopoietic stem cells, facilitating stable engraftment and a potent graft-versus-tumor effect in patients with leukemia and lymphoma who lack a fully matched donor.
- Other names
- Haploidentical BMTPartially HLA-Mismatched Bone Marrow TransplantationNonmyeloablative Haploidentical BMT
Beyond the preview
Go deeper on Haploidentical Bone Marrow Transplantation.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Haploidentical Bone Marrow Transplantation.