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haploidentical natural killer cells + nogapendekin alfa inbakicept
- Development stage
- Phase 1
- Lead developer
- ImmunityBio
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
This experimental combination therapy is being investigated by the University of Minnesota for the treatment of HIV infection. It involves the adoptive transfer of HLA-haploidentical natural killer (NK) cells that have been activated with nogapendekin alfa inbakicept (N-803). Nogapendekin alfa inbakicept is a recombinant interleukin-15 (IL-15) superagonist protein complex consisting of an IL-15 mutant (IL-15N72D) bound to an IL-15 receptor α/IgG1 Fc fusion protein. The therapeutic strategy utilizes N-803 to enhance the proliferation and cytotoxic activity of the donor NK cells, which are then infused into HIV-infected individuals on stable antiretroviral therapy (ART). The primary goal of this Phase 1 pilot study is to evaluate the safety of the approach and its potential impact on reducing the latent viral reservoir.
- Other names
- IL-15 superagonistIL15 superagonistIL 15 superagonistIL-15N72D:IL-15RαSu/Fc complex
02
Targets
IL15RA (Interleukin-15 receptor subunit alpha)IL2RB (IL-2 receptor beta chain)
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