HB4

**HB4** is an experimental, four-component natural-product mixture derived from Huang-Qin Decoction, comprising baicalin, baicalein, glycyrrhizic acid, and wogonin. It was developed in academic research at China Pharmaceutical University and the University of Macau as a chemosensitizing and gastrointestinal-protective adjunct to irinotecan. In colorectal cancer HCT116 models, HB4 enhanced irinotecan-mediated inhibition of cell proliferation and induction of apoptosis; in HCT116 xenograft studies, it showed pharmacological activity comparable with the parent Huang-Qin Decoction, enhanced irinotecan antitumor activity, and reduced irinotecan-associated gastrointestinal toxicity. ([cjnmcpu.com](https://www.cjnmcpu.com/cn/article/doi/10.1016/S1875-5364%2821%2960034-1?viewType=citedby-info))

Other names

baicalin + baicalein + glycyrrhizic acid + wogonin