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HBI-26

Development stage: Preclinical
Lead developer: Human Biome Institute
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics

Overview

HBI-26 is an investigational microbiome-based therapeutic candidate developed by the Human Biome Institute for the treatment of *Clostridioides difficile* infection (CDI). As a live biotherapeutic product (LBP), HBI-26 is designed to restore intestinal microbial homeostasis and provide colonization resistance against *C. difficile* by replenishing beneficial bacterial populations. It is part of a broader pipeline of microbiome-targeted therapies from the Human Biome Institute, which also includes fecal microbiota transplantation (FMT) preparations and defined microbial consortia aimed at treating dysbiosis-related conditions.

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