HBsAg + aluminum hydroxide

A combination vaccine formulation consisting of **hepatitis B surface antigen (HBsAg)** adsorbed onto **aluminum hydroxide** as an adjuvant. HBsAg is a recombinant protein produced by yeast or mammalian cells engineered to express the hepatitis B virus surface antigen. Aluminum hydroxide serves to enhance the immune response by acting as an adjuvant, promoting stronger and longer-lasting antibody production. This combination is standard in recombinant hepatitis B vaccines. The mechanism involves the presentation of HBsAg to the immune system, which induces both humoral and, to a lesser degree, cellular immunity, providing protection against hepatitis B virus infection. Aluminum hydroxide increases antigen uptake and presentation by antigen-presenting cells, favoring a Th2-dominant response that boosts antibody titers[1][5][7].

Other names

hepatitis B surface antigen + aluminum hydroxidehepatitis B vaccine (aluminum hydroxide adjuvant)