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HC-067047
- Development stage
- Preclinical
- Lead developer
- Hydra Biosciences
- Modality
- Small Molecules
- Administration
- Oral, Intraperitoneal
01
Overview
HC-067047 is a potent and selective small molecule antagonist of the Transient Receptor Potential Vanilloid 4 (TRPV4) receptor. It inhibits TRPV4-mediated calcium influx with nanomolar potency across human, rat, and mouse orthologs. In preclinical research, HC-067047 has demonstrated therapeutic potential in animal models of bladder overactivity, cyclophosphamide-induced cystitis, and chronic cough. Additionally, recent studies suggest it may suppress the metastasis of hepatocellular carcinoma by remodeling single-cell polarity. Although widely utilized as a pharmacological tool to study TRPV4 function, it has not progressed to clinical development for human use and is primarily supplied as a research reagent.
- Other names
- 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
02
Targets
TRPV4 (Transient receptor potential cation channel subfamily V member 4)KCNH2 (Voltage-gated potassium channel subfamily H member 2)
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