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HCAR3
- Development stage
- Preclinical
- Lead developer
- ImmunoACT
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
HCAR3 is an autologous chimeric antigen receptor (CAR) T-cell therapy being developed by ImmunoACT. It is designed to target the disialoganglioside GD2, a surface antigen that is highly expressed in various solid tumors, including neuroblastoma and glioblastoma multiforme. The therapy involves the genetic modification of a patient's own T cells to express a CAR specific for GD2, which redirects the immune system to recognize and eliminate GD2-positive malignant cells. Currently in the discovery phase, HCAR3 represents an expansion of ImmunoACT's CAR-T pipeline into solid tumor indications.
- Other names
- ImmunoACT-GD2-CAR-T cell therapyImmunoACT-GD-2-CAR-T cell therapyImmunoACT-GD 2-CAR-T cell therapyGD2-CAR-T cell therapyGD-2-CAR-T cell therapyGD 2-CAR-T cell therapy
02
Targets
GD2
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