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hCSF1R CAR-T cells
- Development stage
- Preclinical
- Lead developer
- Ludwig Maximilian University of Munich
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
hCSF1R CAR-T cells are an experimental chimeric antigen receptor (CAR) T-cell therapy targeting the colony-stimulating factor 1 receptor (CSF1R). Identified through single-cell RNA sequencing (scRNA-seq) analysis of acute myeloid leukemia (AML) patients and healthy tissues, CSF1R was found to be highly expressed on malignant AML cells while being absent on healthy T cells and other vital tissues. Developed by researchers at LMU Munich and the Helmholtz Centre Munich, these CAR-T cells have demonstrated robust anti-tumor efficacy in preclinical models of AML, including patient-derived xenografts (PDX), with minimal off-target toxicity.
- Other names
- anti-CSF1R CAR-T cellsanti-CSF-1R CAR-T cellsanti-CSF 1R CAR-T cellsCSF1R-targeted CAR-T cellsCSF-1R-targeted CAR-T cellsCSF 1R-targeted CAR-T cells
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)
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