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Drug intelligence / Profile preview
HD-MAP pandemic influenza vaccine
- Development stage
- Unknown
- Lead developer
- Vaxxas
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Transdermal
01
Overview
The HD-MAP pandemic influenza vaccine is a needle-free, microarray patch-based immunization candidate developed by Vaxxas, specifically designed for rapid deployment during an influenza pandemic. The platform utilizes a high-density microarray patch (HD-MAP) featuring thousands of vaccine-coated micro-projections that penetrate the outer layers of the skin to deliver the antigen directly to the immune-rich dermis and epidermis. This delivery method targets a high concentration of antigen-presenting cells, such as Langerhans cells and dermal dendritic cells, which can lead to enhanced immunogenicity and potential dose-sparing effects compared to traditional intramuscular injections. The lead pandemic candidate, VX-103, typically incorporates a monovalent H5N1 (avian influenza) recombinant hemagglutinin antigen. A key advantage of this technology is its dry-formulation stability, which may eliminate the requirement for continuous cold-chain storage and simplify logistics in a pandemic scenario.
- Other names
- Vaxxas HD-MAP H5N1 vaccineMicroarray Patch Influenza Vaccine
02
Targets
HA (Hemagglutinin)
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