Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
hdac2 antisense oligonucleotide
- Development stage
- Preclinical
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intrathecal
01
Overview
HDAC2 antisense refers to experimental antisense oligonucleotides (ASOs) designed to target and reduce the expression of histone deacetylase 2 (HDAC2) mRNA. HDAC2 is a histone deacetylase enzyme that acts as a 'memory suppressor' by regulating the expression of genes involved in synaptic plasticity and cognitive function. By base-pairing with HDAC2 mRNA, these ASOs facilitate its degradation, thereby lowering HDAC2 protein levels and potentially restoring memory function. Preclinical studies in mouse models have shown that a single central nervous system injection can lead to long-lasting reductions in HDAC2 and improvements in memory, suggesting potential therapeutic applications for Alzheimer's disease, autism, and other memory-related disorders.
- Other names
- HDAC2 ASOHDAC-2 ASOHDAC 2 ASOHDAC2-targeted antisense oligonucleotideHDAC-2-targeted antisense oligonucleotideHDAC 2-targeted antisense oligonucleotide
02
Targets
Histone deacetylase 2 post-transcriptional end site regulatory RNAHDAC2 (Histone deacetylase 2)
Beyond the preview
Go deeper on hdac2 antisense oligonucleotide.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on hdac2 antisense oligonucleotide.