HEA125 + OKT3

HEA125 + OKT3 is a combination of two monoclonal antibodies. OKT3 (muromonab-CD3) is a murine-derived monoclonal antibody that targets the CD3 receptor complex on human T cells, resulting in rapid depletion or modulation of peripheral T cells and profound immunosuppression[2][5][9]. It was primarily used to reverse acute organ transplant rejection. HEA125, according to available references, is another monoclonal antibody, but publicly available clinical information specifically detailing its molecular target, mechanism, or clinical status is lacking; published work identifies it as an anti-EpCAM (epithelial cell adhesion molecule) monoclonal antibody in certain research, but this is not fully established in current pharmaceutical data. The combination is most likely experimental, aiming to combine T cell depletion (via OKT3) with additional immunomodulatory or tumor-targeting effects (via HEA125, potentially anti-EpCAM), possibly for enhanced anti-tumor effects or improved immunosuppression, paralleling recent strategies that combine anti-CD3 and other T cell-redirecting or tumor-targeting antibodies[6].

Brand names

Orthoclone OKT3

Other names

muromonab-cd3muromonab-cd-3muromonab-cd 3HEA125HEA-125HEA 125