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Healing-University of Messina refers to the therapeutic interventions evaluated in a Phase 4 clinical trial (NCT04845607) sponsored by the University of Messina. The term is derived from the intervention name Healing evaluation recorded in clinical trial metadata, which represents a randomized comparison between two topical treatment protocols for symptomatic oral lichen planus (OLP). The primary active drug in this protocol is clobetasol propionate 0.05% oral gel, a high-potency synthetic corticosteroid that acts as a glucocorticoid receptor agonist to suppress local inflammation and the immune response associated with OLP lesions. The comparative arm of the protocol involves a multi-component anti-inflammatory mouthwash. The study aimed to evaluate clinical healing and symptom reduction over a short-term (5-day) application period.
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