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heat-killed Bifidobacterium dentium
- Development stage
- Preclinical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Heat-killed *Bifidobacterium dentium* is an inactivated preparation of the human-derived probiotic bacterium *B. dentium*. In the context of gastrointestinal research, it is primarily utilized as a non-metabolically active control to evaluate the specific therapeutic contributions of live bacterial metabolites. Research indicates that while live *B. dentium* can significantly enhance the intestinal mucus barrier by upregulating goblet cell markers (such as MUC2, TFF3, and KLF4) and secreting metabolites like acetate and GABA, the heat-killed version generally fails to elicit these same protective effects in germ-free or colitis mouse models. This suggests that the beneficial modulation of the mucus layer by *B. dentium* is dependent on active bacterial metabolism and the secretion of functional molecules rather than purely structural components of the cell wall.
- Other names
- inactivated Bifidobacterium dentium
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