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heat killed Escherichia coli placebo

Development stage: Unknown
Lead developer: International Vaccine Institute
Modality: Vaccines & Immunotherapeutics
Administration: Oral

Overview

Heat killed Escherichia coli placebo is an oral suspension used as a control intervention in clinical trials for killed whole-cell oral cholera vaccines, such as those developed by the International Vaccine Institute (IVI). The placebo is formulated with heat-inactivated E. coli to achieve an optical turbidity identical to the active vaccine, ensuring the maintenance of the double-blind study design. It is primarily used to assess the safety and immunogenicity of cholera vaccines by providing a non-protective comparative baseline in endemic populations.

Other names: Heat Killed E. coli PlaceboE. coli placebo

Targets

PRR (Pattern recognition receptors)

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