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heat-killed Staphylococcus epidermidis BS47C-1
- Development stage
- Preclinical
- Lead developer
- Yonsei University College of Medicine
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Topical
01
Overview
heat-killed Staphylococcus epidermidis BS47C-1 (also referred to as SE2) is a human skin microbiome-derived bacterial strain being developed as a topical treatment for acne vulgaris. Originated from healthy human skin, this heat-killed probiotic strain exhibits anti-inflammatory and skin barrier-supporting properties. In preclinical models, topical application of heat-killed S. epidermidis BS47C-1 significantly downregulates the expression of acne-associated inflammatory mediators (such as IL-1β, IL-6, IL-8, COX-2, iNOS, and TNF-α) induced by Cutibacterium acnes, while also downregulating cytokine and interferon signaling and enhancing skin barrier and antimicrobial gene expression in keratinocytes.
- Other names
- SE2SE-2SE 2Staphylococcus epidermidis BS47C-1heat-killed S. epidermidis BS47C-1heat-killed Staphylococcus epidermidis strain BS47C-1
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