Drug intelligence / Profile preview

heat-treated green tea extract complex

Development stage
Unknown
Lead developer
Amorepacific Corporation
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

The **Heat-treated green tea extract complex** refers to a formulation produced by extracting green tea leaves with ethanol and then subjecting the extract to a prolonged heat treatment (e.g., 115°C for 5 hours), which results in chemical transformation of key catechins—most notably converting epigallocatechin gallate (EGCG) to gallocatechin gallate (GCG)[1]. This modification is intended to enhance biological activity compared to standard green tea extract. Preclinical and clinical studies have investigated its use primarily for **obesity and metabolic syndrome**, often as a dietary supplement. The anti-obesity effects are thought to be mediated by enhanced expression of metabolic and “browning” genes in adipose tissue, activation of PKA and AMPK signaling, inhibition of pancreatic lipase (reducing fat absorption in the gut), increased energy expenditure, and improved glucose tolerance[1][2]. Products are often developed as **oral capsules** for daily administration, and the formulation may be utilized alone or in combination with other bioactive ingredients such as enzymatically modified isoquercitrin (EMIQ)[1].

Other names
heat-treated green tea extractHTGT
02

Targets

PKA (Cyclic amp-dependent protein kinase)AMPK (Adenosine monophosphate–activated protein kinase)PNLIP (Pancreatic triacylglycerol lipase)UCP1 (Uncoupling protein 1)

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