Hebei Medical Univ. HDAC6 compound Cmpd_27

Hebei Medical Univ. HDAC6 compound Cmpd_27: sourced facts only. name: "Among these analogs, compound 27 (Cmpd_27) was identified as the most promising lead, exhibiting potent nanomolar inhibition against HDAC6 with an IC50 value of 4.29 ± 0.12 nM." [PMID:42660046]; target: "Among these analogs, compound 27 (Cmpd_27) was identified as the most promising lead, exhibiting potent nanomolar inhibition against HDAC6 with an IC50 value of 4.29 ± 0.12 nM." [PMID:42660046]; developer: "College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China." [PMID:42660046]; stage: "At the cellular level, Cmpd_27 triggered G2/M phase arrest and induced apoptosis in HCT-116 cells, leading to a significant suppression of cell proliferation (IC50 = 0.69 ± 0.04 μM)." [PMID:42660046]