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Hecolin + hepatitis B vaccine is a co-administered vaccine regimen developed by Xiamen Innovax Biotech for the simultaneous prevention of hepatitis E and hepatitis B infections. Hecolin (HEV 239) is a recombinant virus-like particle (VLP) vaccine expressed in *Escherichia coli*, representing the structural protein of the hepatitis E virus (genotype 1). The hepatitis B component is a recombinant vaccine containing the hepatitis B surface antigen (HBsAg). This combination is primarily evaluated for safety and immunogenicity in healthy adults to simplify immunization schedules in endemic regions where both viruses are prevalent.
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