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hedera helix leaf extract
- Development stage
- Unknown
- Lead developer
- Vefa İlaç
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Tuspamın is an herbal syrup containing *Hedera helix* (ivy) leaf extract, developed and manufactured by the Turkish pharmaceutical company Vefa İlaç. Indicated for the treatment of cough and bronchitis, it functions as a botanical expectorant. The active ingredient, *Hedera helix* leaf extract, works through secretolytic and secretomotor actions to reduce mucus viscosity and facilitate its clearance from the respiratory tract. Additionally, it exhibits spasmolytic properties by indirectly enhancing β2-adrenergic signaling, which helps to relax bronchial smooth muscle. Tuspamın is available over-the-counter in Turkey and is formulated as a 100 ml oral syrup.
- Brand names
- TuspamınTUSPAMIN SURUP
- Other names
- Hedera helix leaf extractIvy leaf extract
02
Targets
GRK2 (G protein-coupled receptor kinase 2)Plasma membrane cholesterol and lipid microdomains (Lipid rafts)ADRB2 (β2)
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