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hederacolchiside A1
- Development stage
- Preclinical
- Lead developer
- Second Affiliated Hospital of Hainan Medical University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Hederacolchiside A1 (HA-1) is a triterpenoid saponin derived from *Hedera helix* (English ivy) that is being investigated as a therapeutic candidate for renal cell carcinoma (RCC). Identified in research by the Second Affiliated Hospital of Hainan Medical University, HA-1 acts as a small molecule inhibitor of ALDH1L2 (Aldehyde dehydrogenase 1 family member L2). ALDH1L2 is an enzyme found to be upregulated in clear cell renal cell carcinoma (ccRCC) following treatment with sunitinib, where it functions to suppress reactive oxygen species (ROS)-mediated ferroptosis, thereby contributing to sunitinib resistance. By inhibiting ALDH1L2, hederacolchiside A1 promotes ferroptosis and restores sensitivity to sunitinib. The compound has been evaluated in RCC organoids, organoid-derived xenograft mouse models, and clinical samples.
- Other names
- Hedera helix sid A1Hederacolchiside A1
02
Targets
Cholesterol
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