Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
hederacoside C
- Development stage
- Preclinical
- Lead developer
- Central South University
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Oral
01
Overview
Hederacoside C (also known as hederasaponin C or kalopanaxsaponin B) is a naturally occurring bisdesmosidic triterpenoid saponin primarily isolated from the leaves of Hedera helix (English ivy) and the stem bark of Kalopanax pictus. It serves as the primary active constituent and pharmacopoeial marker used to standardize ivy leaf extracts (such as EA 575 or Prospan) widely utilized in respiratory therapeutics for their expectorant, mucolytic, and bronchodilating properties. Preclinically, hederacoside C has demonstrated anti-inflammatory, antibacterial, and immunomodulatory activities, including the downregulation of pro-inflammatory cytokines (such as TNF-alpha, IL-1beta, and IL-6) and the inhibition of MAPK/NF-kB signaling pathways. It is also being investigated for its potential therapeutic efficacy in inflammatory conditions such as colitis, mastitis, osteoarthritis, and schistosomiasis japonica.
- Other names
- Akebia saponin PKAkeboside SthGlycoside L-H2Hederasaponin CHederoside H1Kalopanaxsaponin BPericarsaponin PkPulsatilla saponin FTauroside H2Tauroside St-H2
02
Targets
AcetylcholinesteraseEGFR (Epidermal growth factor receptor)IRAK1 (Interleukin-1 receptor-associated kinase 1)
Beyond the preview
Go deeper on hederacoside C.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on hederacoside C.