hedyotis diffusa extract

Hedyotis diffusa extract is derived from the whole plant Hedyotis diffusa (also known as Oldenlandia diffusa), widely used in traditional East Asian medicine for its therapeutic properties. The extract contains multiple bioactive compounds, including anthraquinones, iridoids, flavonoids, polysaccharides, and triterpenes. Reported **mechanisms of action** include induction of apoptosis in cancer cells, inhibition of tumor proliferation and metastasis, suppression of inflammatory pathways, and modulation of immune responses[2][3][5][6]. Key molecular targets and related pathways reported include CTNNB1 (β-catenin), STAT3, CASP8, APC, AKT/ERK, and PI3K/AKT[2][5]. Studies confirm anti-cancer effects in models of lung adenocarcinoma, liver cancer, colorectal cancer, as well as immunomodulatory and anti-inflammatory effects in vitro and in animal models[2][3][4][5][6]. Hedyotis diffusa extract is classed as a **dietary supplement** in most global jurisdictions and is used as a complementary therapy, especially in cancer management, autoimmune conditions, and chronic inflammatory states.

Other names

Hedyotis diffusa extractHedyotis diffusa Willd extractOldenlandia diffusa extractBai Hua She She Cao extract