Drug intelligence / Profile preview

Heiguteng Zhuifeng Huoluo Capsule

Development stage
Unknown
Lead developer
Sinopharm Group Tongjitang Pharmaceutical
Administration
Oral
01

Overview

Heiguteng Zhuifeng Huoluo Capsule (HZFC) is a multi-component traditional Chinese medicine used for the treatment of rheumatoid arthritis and cold arthralgia syndrome. As a Miao ethnomedicine, it is derived from multiple herbal sources, including Sinomenium acutum, Periploca forrestii, and Lygodium paridiformis stenophylla Franch. Studies have identified over 80 chemical constituents, primarily alkaloids, phenylpropanoids, and steroids. The key active alkaloids include sinomenine, dihydrosinomenine, and magnoflorine. The therapeutic effect is believed to stem from its anti-inflammatory properties, which involve the inhibition of NF-κB expression and other inflammatory pathways, leading to a reduction in joint inflammation and providing analgesic effects. It has been marketed in China for many years. [1, 3]

Brand names
Heiguteng Zhuifeng Huoluo Capsule
Other names
HeigutengHeiguteng Zhuifeng Huoluo Jiao Nang
02

Targets

MAOA (Monoamine oxidase A)CNR1 (Cannabinoid receptor 1)FKBP5 (FK506-binding protein 5)ALOX5 (Arachidonate 5-lipoxygenase)EGFR T790M (Epidermal growth factor receptor T790M mutant)MMP1 (Matrix metalloproteinase-1)

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