helium + oxygen

Helium + oxygen (specifically in a 65%/35% ratio) is a medicinal gas mixture developed by Air Liquide for the treatment of severe chronic obstructive pulmonary disease (COPD). The therapy utilizes the physical properties of helium, which is significantly less dense than nitrogen (the primary component of room air). By replacing nitrogen with helium, the mixture reduces gas flow turbulence and airway resistance, thereby decreasing the work of breathing and improving alveolar ventilation. This is particularly beneficial for patients with airflow obstruction who experience dynamic hyperinflation during exercise. Clinical studies, including Phase II trials, have evaluated its impact on exercise capacity, often measured by the 6-minute walk test distance, comparing its efficacy to standard air mixtures and non-invasive ventilation.

Brand names

Heliox

Other names

Helium/Oxygen 65%/35%He/O2 65%/35%Inhalation Helium/Oxygenmedicinal helium/oxygen mixtureHeliox 65/35