Drug intelligence / Profile preview

HEM1036

Development stage
Unknown
Lead developer
HEM Pharma
Modality
Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration
Oral
01

Overview

HEM1036 is an orally administered live biotherapeutic product (LBP) containing a specific strain of the bacterium *Limosilactobacillus fermentum*. Developed by the South Korean biotechnology company HEM Pharma, it is specifically designed to treat Low Anterior Resection Syndrome (LARS), a condition characterized by bowel dysfunction (including fecal urgency, frequency, and incontinence) that often follows sphincter-preserving surgery for rectal cancer. HEM1036 aims to restore the balance of the gut microbiome, which is typically disrupted post-surgery, to improve intestinal homeostasis and alleviate clinical symptoms. The candidate is currently being evaluated in Phase 2 clinical trials.

Other names
limosilactobacillus fermentum

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