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Drug intelligence / Profile preview
Hematopoietic Cell Transplantation-Stanford University-systemic lupus erythematosus
- Development stage
- Unknown
- Lead developer
- Stanford University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Hematopoietic Cell Transplantation-Stanford University-systemic lupus erythematosus refers to a specific therapeutic procedure developed at Stanford University for patients with severe, refractory systemic lupus erythematosus (SLE). The protocol (NCT00325741) utilizes an allogeneic hematopoietic cell transplantation (HCT) approach with a non-myeloablative conditioning regimen. This regimen consists of total lymphoid irradiation (TLI) and rabbit anti-thymocyte globulin (ATG) to deplete the host's autoreactive immune cells without completely destroying the bone marrow. Following conditioning, patients receive an infusion of HLA-matched donor CD34+ hematopoietic stem cells. The goal is to establish stable mixed chimerism, where donor-derived immune cells replace the patient's dysfunctional immune system, potentially leading to long-term remission of life-threatening SLE manifestations in the kidneys, lungs, heart, or central nervous system.
- Other names
- Allogeneic Hematopoietic Cell Transplantation for Patients With Life-Threatening Systemic Lupus ErythematosusAllogeneic Hematopoietic Cell Transplantation (Stanford University SLE Protocol)
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