Drug intelligence / Profile preview

hemay808

Development stage
Phase 2
Lead developer
Tianjin Hemay Biotech
Modality
Hydrogel Systems → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems
Administration
Topical
01

Overview

Hemay808 is a topical ointment formulation containing the novel small molecule Hemay028, developed as a phosphodiesterase 4 (PDE4) inhibitor. It is designed for local application to treat inflammatory skin diseases, primarily atopic dermatitis. By inhibiting PDE4, Hemay808 reduces the breakdown of cyclic AMP in immune cells, thereby decreasing the production of pro-inflammatory cytokines and mediators involved in skin inflammation. The drug aims to provide effective anti-inflammatory action with minimized systemic exposure and toxicity risks due to its topical route of administration. Clinical trials have completed Phase 1 and Phase 2 studies in China for mild-to-moderate atopic dermatitis[1][2][3][4][6].

Brand names
hemay808hemay-808hemay 808
Other names
Hemay028 ointmentHemay-028 ointmentHemay 028 ointment
02

Targets

PDE4 (Phosphodiesterase 4A1)

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