heme-albumin

Heme-albumin is an investigational **heme-bound human serum albumin protein complex** being developed as an intravitreal treatment approach for early retinal degeneration, particularly dry age-related macular degeneration. The complex is intended to transiently induce heme oxygenase-1, enabling heme catabolism to antioxidant and anti-inflammatory products including carbon monoxide and biliverdin. In retinal pigment epithelial-cell models, heme-albumin and its polydopamine nanoparticle delivery formulation reduced oxidative stress and inflammatory signaling; murine intravitreal studies have evaluated tolerability and biocompatible dosing. ([pubs.rsc.org](https://pubs.rsc.org/bm/article/10/24/7004/756178/Sustained-release-of-heme-albumin-as-a-potential))

Other names

heme-bound human serum albuminheme-human serum albumin