Drug intelligence / Profile preview

HemeRX

Development stage
Phase 3
Lead developer
University of Washington
Modality
Small Molecules
Administration
Topical
01

Overview

HemeRX is a topical formulation of racemic epinephrine delivered in the form of medicated pellets, specifically designed for use in restorative dentistry. It is primarily utilized for gingival retraction and local hemostasis (bleeding control) during procedures such as the preparation and placement of dental crowns. As a non-selective adrenergic agonist, it induces local vasoconstriction by stimulating alpha-adrenergic receptors in the gingival tissue. The University of Washington has investigated HemeRX in pediatric populations to assess its cardiovascular safety, specifically monitoring for systemic absorption that could affect heart rate and blood pressure in children undergoing dental treatment under general anesthesia.

Brand names
HemeRX
Other names
racemic epinephrine pelletsepinephrine pellets
02

Targets

ADRA1 (Alpha-1 adrenergic receptor family)ADRB1 (β1)ADRA2 (Adrenergic alpha-2 receptor family)

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