hemopressin

Hemopressin is a nonapeptide (PVNFKFLSH in rats; PVNFKLLSH in humans and mice) derived from the α-chain of hemoglobin[5][3]. It acts as a selective, orally active inverse agonist and antagonist of the CB1 cannabinoid receptor, but does not affect CB2 receptor signaling[7][9][11]. This peptide displays antinociceptive effects, particularly in inflammatory and neuropathic pain models, without typical cannabinoid-related neurological side effects (e.g., hypothermia, catalepsy)[2][3][5]. Hemopressin also regulates blood pressure via peripheral mechanisms linked to nitric oxide release[1][3], reduces food intake in rodents[5], and may modulate processes such as inflammation and differentiation of oligodendroglia[3]. Extended forms of hemopressin (e.g., RVD-hemopressin) show different receptor activities. Hemopressin is being explored both as a potential analgesic and as a component for drug delivery systems in inflammation and cancer[3].

Other names

Hp