Drug intelligence / Profile preview

Hemorrane Plus

Development stage
Discontinued
Lead developer
Faes Farma
Modality
Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration
Rectal, Topical
01

Overview

Hemorrane Plus is a topical rectal ointment for the treatment of uncomplicated haemorrhoids that combines hydrocortisone acetate (the corticosteroid in Hemorrane) with the local anesthetic benzocaine to provide both anti‑inflammatory and analgesic effects.[1][7][11] Hydrocortisone reduces local inflammation, edema, and pruritus by glucocorticoid receptor–mediated vasoconstriction and inhibition of inflammatory mediators, while benzocaine blocks voltage‑gated sodium channels in peripheral nerves to produce localized numbness and rapid relief of pain, burning, and itching.[1][6] The product is being evaluated in multicenter, double‑blind, randomized clinical trials versus hydrocortisone‑only Hemorrane and placebo for short‑term relief of symptoms in adults with grade I–II, non‑thrombosed internal, external, or mixed haemorrhoids.[1][11]

Brand names
Hemorrane Plus
02

Targets

GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)

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