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henagliflozin + retagliptin + metformin
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This triple combination therapy consists of henagliflozin (an SGLT2 inhibitor), retagliptin (a DPP-4 inhibitor), and metformin (a biguanide). It is being evaluated by Peking University First Hospital in collaboration with Jiangsu Hengrui Pharmaceuticals for the treatment of newly diagnosed type 2 diabetes mellitus. Henagliflozin works by inhibiting sodium-glucose cotransporter-2 (SGLT2) in the kidneys to reduce glucose reabsorption. Retagliptin inhibits dipeptidyl peptidase-4 (DPP-4), thereby increasing incretin levels to stimulate insulin secretion. Metformin reduces hepatic glucose production and improves insulin sensitivity. The combination is currently being studied in a Phase 4 trial to compare initial triple therapy against a sequential treatment approach.
- Other names
- Henagliflozin Proline + Retagliptin + MetforminHenagliflozin + Retagliptin + MetforminHenggliptin + Retagliptin + MetforminRegagliptin + Henagliflozin + MetforminRuigeliflozin + Henagliflozin + MetforminHenggeliflozin + Retagliptin + Metformin
02
Targets
ND1 (Mitochondrial electron transport chain complex I)AMPK (Adenosine monophosphate–activated protein kinase)SGLT2 (Sodium-glucose cotransporter protein subunit 2)
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